DNA binding proteins including androgen receptor

Details DNA binding proteins including androgen receptor DNA binding proteins including androgen receptor

1993-11-08

1997-03-25

Chambers, Jasemine C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

43525233, 4353201, 4351723, 435325, 536 231, 935 11, 935 24, 935 29, 935 73, C07H 2104, C12N 1500, C12N 120

Patent

active

056146205

ABSTRACT:
Disclosed are DNA sequences encoding DNA binding polypeptides including androgen receptor (AR) and TR2 polypeptides. Illustratively, human and rat AR-cDNA have 79 kD and 98 kD polypeptide expression products which are immunoprecipitable by human auto-immune anti-androgen receptor antibodies and are capable of binding androgens specifically and with high affinity. Also disclosed are antibodies and immunological methods and materials for detection of androgen receptor and TR2 polypeptides and hybridization methods and materials for detection of AR-and TR2-related nucleic acids.

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