Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-03-15
1999-05-18
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4352523, 4353201, 435325, 536 2431, C07H21/04
Patent
active
059051469
ABSTRACT:
A substantially pure S1-3 protein (a) being a DNA binding protein containing three zinc finger domains, (b) whose mRNA is overexpressed in senescent human diploid fibroblasts or human diploid fibroblasts derived from a patient with Werner Syndrome, and (c) whose mRNA is not expressed in fetal human diploid fibroblasts.
REFERENCES:
Hillier L, et al. EST Database Accession No. T89209, Mar. 20, 1995.
Kaziro, Y.; The role of Guanosine 5'-Triphosphate in Polypeptide Chain Elongation; Biochimica et Biophysica Acta, 505:95-127 (1978).
Arber, S., Halder, et al.; Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell, 79:221-231 (1994).
Argaves, W. S., Tran, et al.; Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure J. Cell Biol., 111:3155-3164 (1990).
Ausubel, F.M., et al.; DNA protein interactions. In: Current Protocols in Molecular Biology, vol. II, Greene Publishing Associates and John Wiley and Sons (1991).
Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W., and Prasher, D.C.; Green fluorescent protein as a marker for gene expression. Science, 263:802-805 (1994).
Call, K.M., Glaser, T., Ito, C.Y., Buckler, A.J., Pelletier, J., Haber, D.A., Rose, E.A., Kral, A., Yeger, H., Lewis, W.H., Jones, C., and Housman, D.E.; Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell, 60:509-520 (1990).
Cristofalo, V.J. and Pignolo, R.J.; Replicative senescence of human fibroblast-like cells in culture. Physiol. Rev., 73:617-638 (1993).
Dice, F.J.; Cellular and molecular mechanisms of aging. Physiol. Rev., 73:149-159 (1993).
Dje, K.J., Mazabraud, A., Viel, A.L., le Maire, M., Denis, H.I., Crawford, E., and Brown, D.D.; Three genes under different developmental control encode elongation factor 1-.alpha. in Xenopus laevis. Nucleic Acids Res., 18:3489-3493 (1990).
Duguid, J.R., Rohwer, R.G., and Seed, B.; Isolation of cDNAs of scrapic-modulated RNAs by subtractive hybridization of a cDNA library. Proc. Natl. Acad. Sci. USA, 85:5738-5742 (1988).
Dulic, V., Drullinger, L.F., Lees, E., Reed, S.I., and Stein, G.H.; Altered regulation of G.sub.1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl. Acad. Sci. USA 90:11034-11038 (1993).
Dulic, V., Kaufmann, W.K., Wilson, S.J., Tisty, T.D., Lees, E., Harper, J.W., Elledge, S.J., and Reed, S.I.; p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell, 76:1013-1023 (1994).
El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parson, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W., and Vogelstein, B.; WAF1, a potential mediator of p53 tumor suppression. Cell, 75:817-825 (1993).
Epstein, C.J., Martin, G.M., Schultz, A.L., and Motulski, A.G.; Werner syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine, 45:177-221 (1966).
Gilles, A.M., Presecan, E., Vonica, A., and Lascu, I.; Nucleoside diphosphate kinase from human erythrocytes. J. Biol. Chem., 266:8784-8789 (1991).
Goldstein S.; The Biology of Aging, in Textbook of Internal Medicine, Section Editor, W.R. Hazzard. Editor-in-Chief, W.N. Kelly, J.B. Lippincott, Philadelphia, 2nd edition, pp. 2336-2342 (1992).
Goldstein S.; Replicative senescence: The human fibroblast comes of age. Science, 249:1129-1133 (1990).
Goldstein S. and Lin C.C.; Rescue of senescent human fibroblasts by hybridization with hamster cells in vitro. Exp. Cell Res. 70:436-439 (1971).
Goldstein, S., Murano, S., Benes, H., Moerman, E.J., Jones, R.A., Thweatt, R., Shmookler Reis, R.J., and Howard, B.H.; Studies on the molecular genetic basis of replicative senescence in Werner syndrome and normal fibroblasts. Exp. Gerontol, 24:461-468 (1989).
Goldstein, S., Moerman, E.J., Fujii, S., and Sobel, B.E.; Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome. J. Cell Physiol., 161:571-579 (1994).
Goldstein, S., Moerman, E.J., and Baxter, R.C.; Accumulation of insulin-like growth factor binding protein-3 in conditioned medium of human fibroblasts increases with chronological age of donor and senescence in vitro. J. Cell Physiol., 156:294-302 (1993).
Goto, J., Rubenstein, J., Weber, J., Woods, K., and Drayna, D.; Genetic linkage of Werner's syndrome to file markers on chromosome. 8. Nature, 355:735-738 (1992).
Grigoriev, V.G., Moerman, E.J., and Goldstein, S.; Overexpression of insulin-like growth factor binding protein-3 by senescent human fibroblasts: Attenuation of the mitogenic response to IGF-1. Exp. Cell Biol., 219:315-321 (1995).
Grigoriev, V.G., Moerman, E.J., and Goldstein, S., Senescence and cell density of human diploid fibroblasts influence metabolism of insulin-like growth factor binding proteins. J. Cell Physiol. 160:203-211 (1994).
Grigoriev, V.G., Tweatt, R., Moerman, E.J., and Goldstein, S.; Expression of senescence-induced protein WS3-10 in vivo and in vitro. Exp. Gerontol, 31:145-157 (1996).
Gyuris, J., Golemis, E., Chertkov, H., and Brent, R.; Cdil, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell, 75:791-803 (1993).
Hara, E., Yamaguchi, T., Nojima, H., Ide, T., Campisi, J., Okayama, H., and Oda, K.; Id-related genes encoding helix-loop-helix proteins are required for G.sub.1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269:2139-2145 (1994).
Hall, C., Sin, W.C., Teo, M., Michael, P., Smith, P., Dong, J.M., Lim, H.H., Manser, E., Spurr, N.K., Jones, T.A., and Lim, L.; .alpha.2-chimerin, an SH2-containing GTYPase-activating protein for the ras-related protein p21.sup.rac derived by alternative splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol. Cell Biol., 13:4986-4998 (1993).
Harley, C.V., and Goldstein, S.; Cultured human fibroblasts: Distribution of cell generations and a critical limit. J. Cell. Physiol., 97:509-516 (1978).
Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., and Elledge, S.J.; The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75:805-816 (1993).
Iwahana H.; A Rapid and Efficient Nonradioactive Method for Screening Recombinant DNA Libraries. Biotechniques, 16:98-102 (1994).
Jarvis, W.D., Kolesnick, R.N., Fornari, F.A., Traylor, R.S., Gerwirtz, D.A., and Grant, S.; Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc. Natl. Acad. Sci. USA, 91:73-77 (1994).
Joseph, L.J., Le Beau, M.M., Jamieson, Jr., G.A., Acharya, S., Shows, T.B., Rowley, J.D., and Sukhatme, V.P.; Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc. Nat'l. Acad. Sci., U.S.A., 85:7164-7168 (1988).
Kadonaga, J.T., Carner, K.R., Masiarz, F.R., and Tijan, R.; Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell, 51:1079-1090 (1987).
Kanzaki, T., Olofsson, A., Moren, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson-Welsh, L., and Heldin, C.; TGF-.beta.1 binding protein: a component of the large latent complex of TGF-.beta.1 with multiple repeat sequences. Cell, 61:1051-1061 (1990).
Kiess, M., Scharm, B., Aguzzi, A., Hajnal, A., Klemenz, R., Schwarte-Waldhoff, I., and Schafer, R.; Expression of ril, a novel LIM domain gene, is down-regulated in HRAS-transformed cells and restored in phenotypic revertants. Oncogene, 10:61-68 (1995).
Koff, A., Ohtsuki, M., Polyak, K., Roberts, J.M., and Massague, J.; Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science, 260:536-539 (1993).
Kolesnick, R. and Golde, D.W.; The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell, 77:325-328 (1994).
Lecka-Czernik, B., Lumpkin, C.K., and Goldstein, S.; An overexpressed gene transcript in se
Adler Benjamin Aaron
Nelson Amy J.
Robinson Douglas W.
University of Arkansas
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