Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Reexamination Certificate
2005-01-18
2008-11-18
Riley, Jezia (Department: 1637)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
C435S005000, C435S006120, C435S007100, C435S007200, C536S023100
Reexamination Certificate
active
07452730
ABSTRACT:
Methods and compositions are provided for forming complexes between dsDNA and novel DNA-binding polymers comprising N-terminal thiophene-containing moieties which exhibit selectivity for T-A base pairs. By appropriate choice of target sequences and DNA-binding polymers, complexes comprising polymer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.
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Dervan Peter B.
Doss Raymond
Foister Shane
Marques Michael A.
California Institute of Technology
Foley & Lardner LLP
Riley Jezia
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