DNA-binding indole derivatives, their prodrugs and immunoconjuga

Details DNA-binding indole derivatives, their prodrugs and immunoconjuga DNA-binding indole derivatives, their prodrugs and immunoconjuga

1996-05-23

1998-12-01

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 23, 514 32, 514 43, 514259, 514283, 514371, 514372, 514377, 514387, 514397, 514407, 514410, 514411, 536 173, 536 286, 536115, 540222, 548181, 548233, 548245, 548246, 5482654, 5483041, 5483117, 5483121, 5483647, 548421, 548425, 548427, 548428, 548433, A61K 3140, A61K 31545, C07D48704, C07D50122

Patent

active

058439374

ABSTRACT:
The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomeric constituents are derived from monocyclic or bicyclic heterocyclic aromatic residues.

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