DNA-based aptamers for human cathepsin G

Details DNA-based aptamers for human cathepsin G DNA-based aptamers for human cathepsin G

2008-01-17

2010-11-23

Whiteman, Brian (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

07838506

ABSTRACT:
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chain length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.

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Vianini et al., “In vitro selection of DNA aptamers that bind L-tyrosinamide,” Bioorganic & Medicinal chemistry, Oct. 2001, pp. 2543-2548, vol. 9, No. 10, Padova, Italy.
Bracht et al., “Isolation and functional characterization of a specific cathepsin G inhibitory aptamer from a pool of synthetic oligonucleotides,” 1996, p. R13, Naunyn-Schmiedeberg's Archives of Pharmacoloty, vol. 353, No. 4.

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