DNA-armed ribozymes and minizymes

Details DNA-armed ribozymes and minizymes DNA-armed ribozymes and minizymes

1995-06-07

2000-07-04

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 911, 4353201, 435366, 536 231, 536 232, 536 245, C12N 1585, C12N 1511, C12N 1563, C07H 2104

Patent

active

060837446

ABSTRACT:
The invention describes catalytic nucleic acid based compounds capable of cleaving nucleic acid polymers both in vivo and in vitro. Two embodiments of this invention are compounds with a short stem that does not base pair, a minizyme, and compounds with DNA hybridizing arms and RNA catalytic domain and stem, DNA-armed ribozymes. The compounds of this invention, while nucleotide based may be substituted or modified in the sugar, phosphate, or base. Methods of use and methods of treatment are also described.

REFERENCES:
patent: 4511713 (1985-04-01), Miller et al.
patent: 4987071 (1991-01-01), Cech
patent: 5023243 (1991-06-01), Tullis et al.
patent: 5149796 (1992-09-01), Rossi
Branch TIBS 23: 45-50 (Feb. 1998) provided in 08/218613 provided in 08/218,613.
Stall et al. Pharm. Res. 12:465-483 (1995).
Boehm, S., (1987) FEBS Letter 220:283-287.
Bruening, G. (1989) Methods of Enzym. 180:546-558.
Cech, T.R. (1987) Science 236:1532-1539.
Chaut, J., et al. (1989) Biochem. & Biophys. Res. Comm. 162:1025-1029.
Cotten, M., et al., (1989) The EMBO Journal 8:3861-3866.
Dahm, S.C., et al. (1990) Biochimie 72:819-823.
Eckner, R. et al., (1991) The EMBO Journ. 10:3513-3522.
Forster, A.C. et al., (1988) NAture 334:265-267.
Goodchild, J., et al. (1991) Archives to Biochem & Biophys. 284 (2):386-391.
Goodchild, J. et al. (1990) Poster No. 12 at Conf. in San Diego.
Haseloff, et al. (1988) Nature 334:585-591.
Huillier, A. et al. Abstract from Conf. proceedings.
Hutchins, C.J. et al. (1986) Nucleic Acids Research 14;3627=3635.
Jeffries, A.C., et al. (1989) Nucl. Acids Res. 17:1371-1377.
Kikuchi, Y., et al., (1991) Nucleic Acids Res. 19:6815-6755.
Koizumi, et al. (1988) FEBS LETTERS 228:228-230.
Koizumi, et al. (1989) Nucleic Acids Res. 17:7059-7071.
Lamb, J.W., et al. (1990) J. Gen. Virol. 71:2257-2264.
McClain et al. (1987) Science 238:527-530.
Miller et al. (1991) Virology 183:711-720.
Perreault, J-P, et al. (1991) Biochem. 30:4020-4025.
Ruffner, D.E. et al. (1989) Gene 82:31-41.
Ruffner, D.E., et al. (1990) Biochemistry 29:10695-10702.
Sampson, et al. (1987) Cold Spring Harbor Sym Quant. Biol. 52:267-275.
Sarver, et al. (1990) Science 247:1222-1224.
Saxena, et al. (1990) J. Biol. Chem. 265:17106-17109.
Scanlon, K. et al. (1991) Proc. Natl. Acad. Sci. 88:10591-10595.
Sheldon, C.C. et al. (1989) Nucleic Acids Res. 17:5665-5678.
Symons, R.H. (1989) Tibs, 14:445-450.
Tabler, M. et al., (1991) Gene 108:175-183.
Uhlenbeck, et al. (1987) Nature 328:596-600.
Yang, et al. (1990) Biochemistry 29:11156-11160.
Zaug, et al. (1986 A) Science, 231:473-474.
Zaug, et al. (1986 B) Nature 234:429-433.
Perreault et al. (1990) Nature 344:565-567.
Forster et al. (1987) Cell 50:9-16.
Uhlmann et al. (1990) Chem. Revs. 90:544-584.

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