DNA and polypeptide for tumor-associated antigen CO-029

Details DNA and polypeptide for tumor-associated antigen CO-029 DNA and polypeptide for tumor-associated antigen CO-029

1990-08-31

1997-09-16

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4351723, 435354, 435365, 435366, 536 231, 536 235, 530350, C10N 1500, C07K 1400, C07H 2102, C07H 2104

Patent

active

056680023

ABSTRACT:
The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-34 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone directs the synthesis of an antigen reactive with monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis reveals that CO-029 belongs to a family of cell surface antigens which includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni.

REFERENCES:
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Classon, et al., "The Primary Structure of the Human Leukocyte Antigen CD37, A Species Homologue of the Rat MRC OX-44 Antigen," The Journal of Experimental Medicine, vol. 169, No. 4, pp. 1497-1502, Apr. 1989.
Sela, et al., "Colon Carcinoma-Associated Glycoproteins Recognized by Monoclonal Antibodies CO-029 and GA22-2," Hybridoma, vol. 8, No. 4, 1989.
Wright et al., "An Immunogenic M 23,000 Integral Membrane Protein of Schistosoma mansoni Worms that Closely Resembles a Human Tumor-Associated Antigen," The Journal of Immunology, vol. 144, No. 8, pp. 3195-3200, 1990.
Szala, et al., "Molecular Cloning of cDNA for the Carcinoma-Associated Antigen GA733-2," Proc. Natl. Acad. Sci., vol. 87, pp. 3542-3546, May 1990.
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