DMF solvates of a .beta.-lactam antibiotic

Details DMF solvates of a .beta.-lactam antibiotic DMF solvates of a .beta.-lactam antibiotic

1990-05-29

1990-12-11

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704

Patent

active

049772570

ABSTRACT:
The crystalline bis(DMF), dihydrate mono(DMF) and mono(DMF) forms of 7.beta.-[2'-(R)-2'-phenyl-2'-aminoacetamido[-3-chloro-3-(1-carbadethiaceph em)-4-carboxylic acid (LY163892) are useful intermediates to the monohydrate form of LY163892.

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patent: 4302541 (1981-11-01), Hirata et al.
patent: 4316958 (1982-02-01), Hirata et al.
patent: 4335211 (1982-06-01), Hashimoto et al.
patent: 4708956 (1987-11-01), Hirata et al.
J. Turner et al., "Absorption, Distribution, Metabolism and Elimination of LY163892 (KT 3772), an Orally Absorbed .beta.Lactam, in Laboratory Animals", Abstract No. 1204, Twenty-Seventh Interscience Conference on Antimicrobial Agents and Chemotherapy, Oct. 4-7, 1987, Program and Abstracts published Aug. 17, 1987.
Merck Index, 10th edition (1983), Entry 1896 (pp. 267-268).
R. Pfeiffer et al., "Crystal Pseudopolymorphism of Cephaloglycin and Cephalexin," Journal of Pharmaceutical Sciences, 59(12), pp. 1809-1814 (1970).

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