Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-09
1999-09-21
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 697, 4353201, 4352523, 536 277, C12P 2102, C12N 1562, C12N 1531
Patent
active
059553049
ABSTRACT:
The invention provides DivIB polypeptides and DNA (RNA) encoding such DivIB, particularly those of S. aureus, and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such DivIB for the treatment of infection, to screen for antagonists against such DivIB, diagnostic assays for detecting disease.
REFERENCES:
Harry, et al., "Conservation of the 168 div1B gene in Bacillus subtilis W23 and B. licheniformis, and evidence for homology to ftsQ of Escherichia coli." Gene, vol. 147, pp. 85-89 (1994).
Harry, et al., "Expression of divIB of Bacillus subtilis during Vegetative Growth." J. Bacteriology, vol. 176, No. 4, pp. 1172-1179, Feb. 1994.
Harry, et al., "Characterization of mutations in div1B of Bacillus subtilis and cellular localization of the Div1B protein." Molecular Biology, vol. 7, No. 4, pp. 611-621 (1993).
Harry, et al., "Cloning and Expression of a Bacillus subtilis Division Initiation Gene for Which a Homolog Has Not Been Identified in another Organism." J. Bacteriology, vol. 171, No. 12, pp. 6835-6839, Dec. 1989.
Descoteaux, et al., "Regulation of Cell Division in Escherichia coli K-12: Probable Interactions among Proteins FtsQ, FtsA, and FtsZ." Journal of Bacteriology, vol. 169, No. 5, pp. 1938-1942 May 1987.
Carson, et al., "The FtsQ Protein of Eschrichia Coli: Membrane Topology, Abundance, and Cell Division Phenotypes Due to Overproduction and Insertion Mutations." Journal of Bacteriology, vol. 173, No. 7, pp. 2187-2195, Apr. 1991.
Wang, et al., "A factor that positively regulates cell division by activating transcription of the major cluster of essential cell divsion gene of Escherichia coli." The EMBO Journal, vol. 10, No. 11, pp. 3363-3372 (1991).
Nukushina, et al., "Genetic Analysis of the Developmental Processes During Germination and Outgrowth of Bacillus Subtilis Spores With Temperature-Sensitive Mutants." Genetics, vol. 68, pp. 63-74 (1969).
Callister, et al., "Characterization and Mapping of Temperature-Sensitive Division Initiation Mutations of Bacillus subtilis." J. Bacteriology, vol. 145, No. 2, pp. 1042-1051, Feb. 1981.
Dai, et al., "Topological Characterization of the Essential Escherichia coli Cell Divison Protein FtsN." J. Bacteriology, vol. 178, No. 5, pp. 1328-1334, Mar. 1996.
Rowland, et al., "Div1B, FtsZ and cell division in Bacillus subtilis." Molecular Microbiology, vol. 23, No. 2, pp. 295-302, (1997).
Storts, et al., "Overproduction and Identification of the ftsQ Gene Product, an Essential Cell Division Protein in Escherichia coli K-12." J. Bacteriology, vol. 171, No. 8, pp. 4290-4297, Aug. 1989.
Pucci, M.J., et al. (1997) J. Bacteriol. 179(17). 5632-5635.
Sato, Y, et. al. (1996) Science 273, 352-354.
Hodgson John Edward
Payne David John
Pearson Stewart Campbell
Gimmi Edward R.
Jackson Arthur E.
King William T.
Patterson Jr. Charles L.
SmithKline Beecham Corporation
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