Divalent hapten derivatives

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic

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436500, 436816, G01N 33546

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active

053366212

ABSTRACT:
Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formula

REFERENCES:
patent: 4341758 (1982-07-01), Sakakibora et al.
patent: 4581337 (1986-04-01), Frey et al.
patent: 4604365 (1986-08-01), O'Neill et al.
Pauling, L. et al. "Precip. Reactions of Antibodies & Polyhaptenic Substances." Journal Amer. Chem. Soc., vol. LXIV, 1942, pp. 2994-3003.
Nishikawa, T. et al. "Comp. Neph. Immuno. Method . . . ". Journal Immunological Methods, 29 (1979), pp. 85-89.
Green et al., "Detection of Antibody Monomers, Dimers, and Polymers upon interaction of A Homologous Series of Divalent Haptens w/its Specific Ab.", Biochem. & Biophys Res Comm. vol. 46, No. 2 1972, pp. 738-744.
Nishikawa, et al., Competitive Nepholometric Immunoassay Method for Antiepilectic Drugs in Patient Blood, Journal of Immunological Method, 29 (1979) pp. 85-89.

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