Diuretic imidazole derivatives

Details Diuretic imidazole derivatives Diuretic imidazole derivatives

1982-12-03

1985-05-14

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548342, 548343, A61K 31415, C07D23364

Patent

active

045171980

ABSTRACT:
The invention provides compounds of the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined hereinbelow. These compounds exhibit valuable pharmacological activity and are useful in the treatment of mammals, e.g. as diuretic agents. Furthermore, they have antithrombotic and anti-hypertensive effects.

REFERENCES:
Chemical Abstracts, 78: 25740q (1973) [Wilkinson, et al., Biochem. Pharmacol. 1972, 21(23), 3187-3192].
Chemical Abstracts, 82: 39231u (1975) [Wilkinson, et al., Pestic. Biochem. Physiol. 1974, 4(3), 299-312].
Yamauchi, O., et al., Chem. Pharm. Bull. 15 (10), pp. 1453-1460, (1967).
Swett, L., et al., J. Med. Chem. 13 (5), pp. 968-970 (1970).
B. N. Craver, et al., Arch. Int. Pharmacodyn., 87, 33-48 (1951).
C. F. Wilkinson, et al., Biochem. Pharm., 21, 3187-3192 (1972).
C. F. Wilkinson, et al., Pesticide Biochem. Phys., 4, 299-312 (1974).

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