Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-06
1998-02-10
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
057169705
ABSTRACT:
A diuretic compound of Formula I ##STR1## or pharmaceutically acceptable salt thereof where R.sup.1 is a C.sub.1-6 alkyl; R.sup.2 is halogen, C.sub.1-4 alkyl; and R.sup.3 is C.sub.1-4 alkoxy are disclosed, preferably, benzamide, 3-chloro-N-(2-ethyl-2-(3-methoxyphenyl)-4-(1-piperidinyl)butyl), monohydrochloride. The compounds are effective diuretics which increase the excretion of water with little increase in electrolyte excretion.
REFERENCES:
patent: 3103516 (1963-09-01), Schmitt et al.
patent: 5236921 (1993-08-01), Edmonds et al.
patent: 5350852 (1994-09-01), Edmonds et al.
Schmitt, K. et al, Arch. Pharm. 1962, 295, pp. 744-753.
Curry James T.
Humphrey Stephen J.
Jacobsen E. Jon
Corneglio Donald L.
Dahlen Garth M.
Dentz Bernard
Pharmacia & Upjohn Company
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