Diuretic composition

Details Diuretic composition Diuretic composition

1988-01-15

1989-12-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424482, A61K 936

Patent

active

048881791

ABSTRACT:
The present invention relates to a multiple-unit dose composition comprising furosemide as pharmaceutically active compound, whereby the composition gives a release of furosemide in accordance with Dissotest in a buffer having pH 1.5 of at most 4% during hour 1, a release in a buffer having pH 5.5 of at most 7.5% during a consecutive hour (hour 2), a release of furosemide in a buffer having pH 7.5 of at least 65% during a further consecutive hour (hour 3), and a release of furosemide in a buffer having pH 7.5 of at least 90% during a consecutive hour (hour 4).

REFERENCES:
patent: 4716041 (1987-12-01), Kjornaes et al.
patent: 4728512 (1988-03-01), Mehta et al.

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