Diuretic antiturombogenic and antiarrhythmic processes using N-s

Details Diuretic antiturombogenic and antiarrhythmic processes using N-s Diuretic antiturombogenic and antiarrhythmic processes using N-s

1975-03-24

1976-12-28

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

A61K 3140

Patent

active

040003043

ABSTRACT:
2-(2- or 3-Indolyl)indolines, unsubstituted and carbon substituted, condense with N-mono substituted carboxamides or with lactams under the influence of phosphorus oxychloride to produce 1-(N-substituted iminoalkyl)-2-(2- or 3-indolyl)indolines. The 2-(3-indolyl)-1-[2-(1-pyrrolinyl)]indolines rearrange to produce benzodiazepine derivatives. These products have diuretic, antituromobogenic, and antiarrhythmic activity on oral administration.

REFERENCES:
patent: 3637748 (1972-01-01), Psaar et al.
patent: 3679702 (1972-07-01), Wu et al.
Ryan et al., Tetrahedron 12, pp. 2325-2337 (1971).
Wu et al., Jour. of Med. Chem. 15, pp. 529-534 (1972).
Amer et al., Research Communications in Chemical Pathology and Pharmacology 4, pp. 467-475 (1972).

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