Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Para-n-benzene - sulfoxy-n containing doai – and said benzene...
Patent
1982-10-14
1985-06-11
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Para-n-benzene - sulfoxy-n containing doai, and said benzene...
514259, A61K 31635
Patent
active
045228183
ABSTRACT:
A combination tablet containing metolazone and triamterene is useful in diuretic therapy and the treatment of hypertension. The composition is advantageous in the prevention of hypokalemia, a common side effect of diuretic therapy and possesses enhanced dissolution properties. Proper selection of the excipient formulation permits preparation of the tablets by direct compression.
REFERENCES:
patent: 3081230 (1963-03-01), Weinstock et al.
patent: 3360518 (1967-12-01), Shetty
Matochik, T., Paper Submitted for Internship Research Credit at Pennwalt Corp.: The In Vivo, In Vitro Analysis of a Fixed Combination Diuretic by Reversed Phase High Pressure Liquid Chromatography, Sent to Rochester Institute of Technology 1979; on File in RIT Chemistry Library.
Di-Tab Bulletin, Stauffer Chemical Co., Aug. 1981.
Hohenegger, M. et al., Int. J. Clin. Pharmacol. 1976, 13(4), 298-303.
Onesti G., Drug Therapy, 66-78 (6/1975).
Zeller J., Current Therapeutic Research, 29(4), 45-1 to 45-8 (1981).
Hollifield J., et al., In Systemic Effects of Antihypertensive Agents (Sambhi M.-Editor), Symposia Specialists, 1976, pp. 131-155.
Chemical Abstracts, 85: 104041k (1976) [Hohenegger, M., et al., Int. J. Clin. Pharmacol. Biopharm. 1976, 13(4), 298-303].
Pennwalt Corporation
Schwartz Richard A.
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