Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-11-05
1986-02-11
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546116, A61K 31435, C07D491048
Patent
active
045699380
ABSTRACT:
This invention relates to new 1,3-dihydro-6-methyl-furo-(3,4-c)-pyridine derivatives of the general formula: ##STR1## wherein, each of A.sub.1 and A.sub.2 represents various hydrocarbon groups, to pharmaceutically acceptable salts of them, to a process for the preparation of said derivatives from the corresponding 6-hydroxy compounds, treated by ethyl bromoacetate and then hydrolyzed. The invention further provides pharmaceutical compositions wherein said derivatives are used as active ingredients. The compounds are useful as diuretics, in lowering blood pressure and as antihistaminics.
REFERENCES:
March, Advanced Chemistry, 2nd ed., McGraw-Hill, (1977), p. 357.
Morrison & Boyd, Organic Chemistry, 3rd ed., pp. 677, 556.
Garay et al., Stimulation of K+ Fluxes . . . Cells, Biochem. Pharmacol., vol. 33, No. 13, pp. 2013-2020, (1984).
Schwartz Richard A.
Societe de Conseils de Recherches et d'Applications Scientifique
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