Diuretic and antihypertensive substituted-5-pyrimidinesulfonylur

Details Diuretic and antihypertensive substituted-5-pyrimidinesulfonylur Diuretic and antihypertensive substituted-5-pyrimidinesulfonylur

1988-04-26

1989-08-01

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546294, 544323, C07D23946, A61K 31505

Patent

active

048533890

ABSTRACT:
This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active ingredient and methods of treatment where there is an indicated need for an antihypertensive and/or diuretic agent.

REFERENCES:
patent: 3817998 (1974-06-01), Anderson
patent: 4018929 (1977-04-01), Delarge
patent: 4244950 (1981-01-01), De Ridder
J. Delarge et al., Ann. Pharm. Fr., 32(12), 657-667 (1974).
J. Delarge et al, Eur. J. Med. Chem.--Chimica Therapeutica, 15, 299-304 (1980).

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