Diuretic 6-vinyl-furo-(3,4-c)-pyridine derivatives

Details Diuretic 6-vinyl-furo-(3,4-c)-pyridine derivatives Diuretic 6-vinyl-furo-(3,4-c)-pyridine derivatives

1984-11-05

1986-02-11

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546116, A61K 31435, C07D491048

Patent

active

045699399

ABSTRACT:
This invention relates to new 1,3-dihydro-6-vinyl-7-hydroxy-furo-(3,5-c)-pyridine derivatives of the general formula: ##STR1## wherein each of A.sub.1 and A.sub.2 independently represents various hydrocarbon substituents, to a process for the preparation of these compounds from the corresponding 7-chloromethyl derivative and to pharmaceutical composition containing them. The compounds are useful as diuretics.

REFERENCES:
Strietweiser, Jr. et al., Introduction to Organic Chemistry, MacMillan Pub. (1976), pp. 388-389.
Garay et al., Biochem. Pharmacol., 1984, 33(13), 2013-20; Chem. Abs. 101:122749a.

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