Diurea derivatives useful as medicaments and processes for the p

Details Diurea derivatives useful as medicaments and processes for the p Diurea derivatives useful as medicaments and processes for the p

1992-06-30

1993-07-13

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546308, 546309, 564 27, 564 29, 564 50, 564 52, 564 53, 564 54, 564 55, 564 56, 564 57, 564 59, C07D21383

Patent

active

052274926

ABSTRACT:
Diurea derivatives are provided which can be represented by the following general formula and salts thereof: ##STR1## Illustrative derivatives include 1,3-bis[[1-cycloheptyl-3-(3-pyridyl)ureido]-methyl]benzene, 1,3-bis[[1-cycloheptyl-3-(2-pyridyl)ureido]-methyl]benzene, and 1,3-bis[[1-cycloheptyl-3-(4-pyridyl)ureido]-methyl]benzene.
The above compounds inhibit acyl-coenzyme A cholesterol acyltransferase (ACAT enzyme), and thereby control the accumulation of cholesterol ester to the smooth muscle of arterial wall in the blood vessel.

REFERENCES:
patent: 3676446 (1972-07-01), Schorr et al.
patent: 4216228 (1980-08-01), Yamada et al.
patent: 4294833 (1981-10-01), Innocenti et al.
patent: 4387105 (1983-06-01), DeVries et al.

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