Dithranol compositions stabilized with alpha hydroxyacids

Details Dithranol compositions stabilized with alpha hydroxyacids Dithranol compositions stabilized with alpha hydroxyacids

1979-09-24

1981-09-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424279, 424313, 424317, 424320, 424365, A61K 3105

Patent

active

042872146

ABSTRACT:
Chemically stable dithranol compositions useful as topical treatment for inflammatory disorders such as psoriasis, eczema and seborrheic dermatitis are disclosed. Incorporation of a certain alpha hydroxyacid as its free acid, lactone, amide or salt form in dithranol containing compositions has been found to chemically stabilize said compositions. The alpha hydroxyacids include glyceric acid, gluconic acid, galacturonic acid, glucuronic acid, glucoheptonic acid, galactonic acid, malic acid, mucic acid, citric acid, saccharic acid, tartaric acid, tartronic acid, isocitric acid and glucuronamide. A single member of the above alpha hydroxyacids may be present in a total amount of from 0.01 to 1 percent by weight of the total composition, or a plurality thereof may be present in a preferred concentration range of from 0.02 to 0.5 percent by weight of the total composition.

REFERENCES:
patent: 3920835 (1975-11-01), Van Scott et al.
Chemical Abstracts 78:75809q, (1973).
Sagarin-Cosmetics, Science & Technology, pp. 1066-1067, (1957).

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