Dithiolanylglycine-containing HIV protease inhibitors of the hyd

Details Dithiolanylglycine-containing HIV protease inhibitors of the hyd Dithiolanylglycine-containing HIV protease inhibitors of the hyd

1993-05-10

1995-06-13

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544360, 544365, 546169, 546194, 546273, 546284, C07K 502

Patent

active

054244269

ABSTRACT:
The invention relates to dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type of the general formula (I) ##STR1## processes for their preparation and their use as retroviral agents.

REFERENCES:
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patent: 5162538 (1992-11-01), Voges et al.
Joel R. Huff, "HIV Protease: A Novel Chemotherapeutic Target for AIDS", Journal of Medicinal Chemical, vol. 34, No. 8, pp. 2304-2314 (Aug., 1991).
J. Hansen et al., "Partial Purification . . . Antibody", The EMBO Journal, vol. 7, No. 6, pp. 1785-1791 (1988).
R. Pauwels et al., "Rapid and automated . . . anti-HIV compounds", Journal of Virological Methods, 20, pp. 309-321 (1988).
P. Buhlmayer et al., "Synthesis and Biological . . . Human Renin", J. Med. Chem., 31, pp. 1839-1846 (1988).
D. J. Plata, et al., "The Stereospecific . . . Template", Tetrahedron Letters, vol. 32, No. 30, pp. 3623-3626 (1991).
D. H. Rich, et al., "L-687,908, a Potent . . . Inhibitor", J. Med. Chem., 34, pp. 1225-1228 (1991).
M. P. Mertes et al., "w-Dithiolano Amino Acids", J. Med. Chem., 12, pp. 342-343, (1969).

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