Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-08-22
1991-08-20
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142322, 514442, 544111, 544145, 544374, 549 38, 546207, 546208, C07D41304, C07D41314, C07D33906, A61K 31385
Patent
active
050414402
ABSTRACT:
Novel dithiolane derivatives of formula: ##STR1## wherein X is, a C.sub.2 -C.sub.7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C.sub.1 -C.sub.4 alkyl, and C.sub.1 -C.sub.4 alkoxy; Y represents C.sub.2 -C.sub.7 alkylcarbonyl group, C.sub.2 -C.sub.7 alkoxycarbonyl group or cyano group; and R represents di (C.sub.1 -C.sub.4 alkylamino) group, morpholino group or piperidino group, are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis of hepatitis and other hepatic disorders.
REFERENCES:
patent: 4535075 (1985-08-01), Kurono et al.
patent: 4668799 (1987-05-01), Yoshizawa et al.
Morrison and Boyd, Organic Chemistry, 4th Ed. (1983), Allan and Bacon, Inc., p. 894.
Chemical Abstract, Dec. 1988, vol. 109, No. 23, p. 667, Abstract No. 211056E.
Hiraga Kunikazu
Kubota Shuhei
Nakayama Keisuke
Uchida Matazaemon
Datlow Philip
Nihon Nohyaku Co. Ltd.
Shah Mukund J.
LandOfFree
Dithiolane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dithiolane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dithiolane derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1008161