Dithiolan derivatives, their preparation and their therapeutic e

Details Dithiolan derivatives, their preparation and their therapeutic e Dithiolan derivatives, their preparation and their therapeutic e

1998-03-31

2000-01-11

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142278, 5142315, 514255, 514336, 514360, 514365, 514369, 514397, 544 60, 544145, 544379, 546207, 5462807, 548123, 548183, 548200, 5483151, 548467, 548527, 549 39, A61K 31385, C07D33904

Patent

active

060136634

ABSTRACT:
A compound of formula (I): ##STR1## wherein one of m and n represents 0, and the other represents 0, 1 or 2; k represents 0 or 1 to 12; R.sup.1 is hydrogen, an aryl, a heterocyclic, an alkyl, a hydroxy or --OR.sup.7, wherein R.sup.7 is an alkyl, an alkenyl or an aralkyl; A is --CON(R.sup.2)SO.sub.2--, wherein R.sup.2 is hydrogen, an alkyl or an aralkyl; B is a single bond; and pharmaceutically acceptable salts thereof. The compounds have the ability to enhance the activity of glutathione reductase and can therefore be used for the treatment and prevention of a variety of diseases including cataracts.

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