Dithiocarbamate antiviral agents and methods of using same

Organic compounds -- part of the class 532-570 series – Organic compounds – Esters having the thiocarboxylate group – -cx- – wherein the...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S005000

Reexamination Certificate

active

10483975

ABSTRACT:
The invention discloses a use of dithiocarbamate compounds having the structural formula R1R2NCS2H, in which R1and R2, independently of each other, represent a straight or branched C1-C4alkyl, or, with the nitrogen atom, form an aliphatic ring with 4 to 6 C atoms, in which R1, R2, or the aliphatic ring is optionally substituted with one or more substituents selected from OH, NO2, NH2, COOH, SH, F, Cl, Br, I, methyl or ethyl, and oxidized forms of these compounds, in particular dimers thereof, as well as pharmaceutically acceptable salts thereof, to prepare an agent for treating or preventing an infection by RNA viruses which attack the respiratory tract and cause disease there.

REFERENCES:
patent: 5686436 (1997-11-01), Van Dyke
patent: 6093743 (2000-07-01), Lai et al.
patent: 1963223 (1969-12-01), None
patent: 2555730 (1976-06-01), None
patent: 861043 (1961-02-01), None
patent: 51139632 (1976-12-01), None
patent: WO95/03792 (1995-02-01), None
patent: WO96/10402 (1996-04-01), None
patent: WO99/08665 (1999-02-01), None
patent: WO99/64068 (1999-12-01), None
patent: WO99/66918 (1999-12-01), None
patent: WO 01/51046 (2001-07-01), None
Elisabeth Gaudernak, Joachim Seipelt, Andrea Triendl, Andreas Grassauer, and Ernst Kuechler Antiviral Effects of Pyrrolidine Dithiocarbamate on Human Rhinoviruses Journal of Virology , Jun. 2002, p. 6004-6015, vol. 76, No. 12.
Jay G Calvert and Edward H Simon Effects of the Copper Chelators Diethyldithiocarbamate and Bathocuproine Sulfonate on Interferon and Its Antiviral State Journal of Interferon Research 10:13-23 (1999).
Baum and Paulson, “Sialyloligosaccharides of the respiratory epithelium in the selection of human influenza virus receptor specificity,”Acta Histochemica, Suppl., S35-38, 1990.
Calvert, “Effects of the copper chelators diethyldithiocarbamate and bathocuproine sulfonate on interferon and its antiviral state,”Interferon Research, 10:13-23, 1990.
Dollery, In:Therapeutic Drugs, Second Ed., vol. 1, Churchill Livingstone, Edinburgh, 1999.
Fields et al., In:Virology, 3rdEdition, Lippencott-Raven Publ., Philadelphia, vol. 1, 434-436, 1995.
Flory et al., “Influenza virus-induced NF-κB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activationof IκB kinase,”J. Biol. Chem., 275(12):8307-8314, 2000.
Gorman et al., “Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses,”J. Virol., 65(7):3704-3714, 1991.
Grambas and Hay, Maturation of influenza A virus hemagglutinin-estimates of the pH encountered during transport and its regulation by the M2 protein,Virology, 190:11-18, 1992.
Grambas et al., “Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses,”Virology, 191:541-549, 1992.
Hinshaw and Webser, “The perpetuation of orthomyxoviruses and paramyoxviruses in Canadian waterfowl,”Can. J. Microbiol., 26:622-629, 1980.
Knobil et al., “Role of oxidants in influenza virus-induced gene expression,”Am. J. Physiol., 274(1):134-142, 1998.
Ludwig et al., “European swine virus as a possible source for the next influenza pandemic?”Virology, 212:555-561, 1995.
Meyer et al., “H202 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor,”EMBO J., 12:2005-2015, 1993.
Rogers and Paulson, “Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin,”Virology, 127:361-373, 1983.
Schwarz et al., “Nf-κB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice,”J. Virology, 72(7):5654-5660, 1998.
Sherman et al., “Pyrrolidine dithiocarbamate inhibits induction of nitirc oxide synthase activity in rat alveolar macrophages,”Biochem. Biophys. Res. Comm., 191(3):1301-1308, 1993.
Tai et al., “Activation of nuclear factor κB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis,”Hepatology, 31(3):656-664, 2000.
The HIV87 Study Group. “Multicenter, randomized, placebo-controlled study of ditiocarb (Imuthiol) in human immunodeficiency virus-infected asymptomatic and minimally symptomatic patients,”AIDS Res Hum Retroviruses; 9:83-89, 1993.
Virus Taxonomy: The Classification and Nomenclature of Viruses. The Seventh Report of the International Committee on Taxonomy of Viruses, Regenmortet et al. (ed.), Academic Press, SanDiego, 657-673, 2000.
Yen, “Nuclear factor κB and hepatitis C-is there a connection?”,Hepatology, 31(3):785-787, 2000.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Dithiocarbamate antiviral agents and methods of using same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dithiocarbamate antiviral agents and methods of using same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dithiocarbamate antiviral agents and methods of using same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3824247

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.