Dithienylpiperidines, pharmaceutical compositions thereof, and m

Details Dithienylpiperidines, pharmaceutical compositions thereof, and m Dithienylpiperidines, pharmaceutical compositions thereof, and m

1980-01-14

1981-08-11

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546213, 546212, 542430, 542432, A61K31138, C07D40914, A61K 31445

Patent

active

042834058

ABSTRACT:
There are prepared compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or together represent a second bond between the carbon atom carrying R.sub.1 and R.sub.2, R.sub.1 also can be a hydroxy group, R.sub.3 is hydrogen, a C.sub.3 -C.sub.8 cycloalkyl group or a C.sub.1 -C.sub.20 alkyl group, which optionally can also contain one or two hydroxy groups and the groups R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and are hydrogen, C.sub.1 -C.sub.6 -alkyl groups or halogen atoms, their N-oxide, their quaternary salts and their acid addition salts. There are also described processes for their production. The compounds possess especially an antischemic and blood pressure increasing activity.

REFERENCES:
patent: 2739968 (1956-03-01), Sperber et al.
patent: 5175088 (1979-11-01), Kleeman et al.
Waldvogel, "Helv. Chim. Acta" vol. 59 pp. 866-877 (1979).
Olofson et al., "Tetrahedron Letters" (1977) pp. 1567-1970.
Fodor et al., "J. Org. Chem." vol. 39, No. 11 (1974) pp. 1507-1516.

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