Dithienylalkylamines and process for their production

Details Dithienylalkylamines and process for their production Dithienylalkylamines and process for their production

1978-01-05

1980-06-03

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424275, 42424851, 542423, 542414, 542424, 542425, 544146, 544379, 549 59, 2603303, C07D40914

Patent

active

042062136

ABSTRACT:
There are prepared compounds of the formula ##STR1## where >A--B-- has either the structure >C(OH)--CH.sub.2 -- or the structure >C.dbd.CH, Alk is a straight or branched chain C.sub.1 -C.sub.5 - alkylene group and -NHY is ##STR2## where R' is hydrogen, phenyl, phenyl substituted once or twice by C.sub.1 -C.sub.4 -alkyl groups, a C.sub.1 -C.sub.4 -alkoxy group or by halogen atoms, a C.sub.1 -C.sub.6 -alkyl group, a C.sub.1 -C.sub.4 -hydroxyalkyl group or a phenalkyl group whose alkyl portion consists of 1-4 carbon atoms or such a phenalkyl group containing 1 to 3 C.sub.1 -C.sub.4 -alkoxy group substituents. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

REFERENCES:
patent: 3002946 (1961-10-01), Janssen
patent: 3145204 (1964-08-01), Mauvernay
patent: 3330825 (1967-07-01), Thiele et al.
patent: 3687945 (1972-08-01), Thiele et al.
patent: 3766173 (1973-10-01), Thiele et al.
Robba et al., Chim. Ther., 1973, No. 1, p. 22-31.
Thiele et al. (D), Chem. Abst. 74 (1971), 76320.
Thiele et al. (E), Chem. Abst. 71 (1969), 91188.
Thiele et al. (F), Chem. Abst. 77 (1970), 61799.

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