Dithiazole compounds, matrix metalloprotease inhibitors and...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

Reexamination Certificate

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C514S360000, C548S123000

Reexamination Certificate

active

07348017

ABSTRACT:
A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of skin conditions.

REFERENCES:
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Inomata et al. “Possible Involvement of Gelatinases in Basement Membrane Damage and Wrinkle Formation in Chronically Ultraviolet B-exposed Hairless Mouse” The Journal of Investigative Dermatology 2003, vol. 120, No. 1, pp. 1-7.
Amano et al. “Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process” British Journal of Dermatology 2005, vol. 153, Suppl 2, pp. 37-46.
Gary J. Fisher et al., “Molecular basis of sun-induced premature skin ageing and retinoid antagonism”, Nature 1996, vol. 379, pp. 335-339.
Gary J. Fisher et al., “Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light”, The New England Journal of Medicine, vol. 337, No. 20, pp. 1419-1428.
Kaori Miyazaki et al. “Matrix metalloproteinases: Their structures and functions, with special reference to their roles in tumor invasion and metastasis”, Biochemistry 1996, vol. 68, No. 12, pp. 1791-1807.

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