Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2010-02-25
2011-12-27
Borin, Michael (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S027000
Reexamination Certificate
active
08086413
ABSTRACT:
A method, computer system, and computer program product for determining N disulphide bond connections in a protein having 2N bonded sulphur atoms. Each sulphur atom is available for forming the N disulphide bond connections through use of an undirected graph having the 2N sulphur atoms as nodes and having an edge connecting each pair of nodes. Each sulphur atom is comprised by a cysteine of the protein. The cysteines are sequenced along a chain in the protein as ordered list of position indexes. A weight W of each edge between cysteine position indexes I1and I2is calculated as decreasing with increasing separation d between I1and I2, wherein d is |I1−I2|/100. The N disulphide bond connections are determined by optimizing an objective function formed from the calculated weights W.
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Borin Michael
International Business Machines - Corporation
Pivnichny John
Schmeiser Olsen & Watts
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