Disulfide linked immunotoxins with molecular groupings in the li

Details Disulfide linked immunotoxins with molecular groupings in the li Disulfide linked immunotoxins with molecular groupings in the li

1991-06-19

1994-08-16

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

4241791, 4241551, 4241541, 5303911, 5303913, 5303915, 5303917, 5303919, 530404, 530408, A61K 3944, C07K 1702, C07K 1528

Patent

active

053385420

ABSTRACT:
The efficacy of immunotoxins having an antibody that recognises a tumour associated antigen linked to a cytotoxin through a heterobifunctional agent of the disulphide type is improved by providing in the heterobifunctional agent a molecular grouping creating steric hindrance in relation to the disulphide link. This steric hindrance can be provided by a methyl substituted methylene group located in the heterobifunctional link adjacent to the disulphide bond.

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