Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-04-19
2005-04-19
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S014800, C514S015800, C530S300000, C530S344000
Reexamination Certificate
active
06881718
ABSTRACT:
The invention pertains to the discovery of novel disulfide linked cell toxins which can ablate NK-1 receptor expressing cells. These toxins are used as pharmaceutical compositions for the ablation of NK1 receptor expressing cells and comprise a substance P (SP)-Pseudomonasexotoxin disulfide linked conjugate. The invention also includes methods of making and using these toxins and pharmaceutical compositions.
REFERENCES:
patent: 5141248 (1992-08-01), Haldric et al.
patent: 5169933 (1992-12-01), Anderson et al.
patent: 5633351 (1997-05-01), Reed
patent: 5663250 (1997-09-01), Potter et al.
patent: 5667255 (1997-09-01), Kato
patent: 5668255 (1997-09-01), Murphy
patent: 5747641 (1998-05-01), Frankel et al.
patent: 6632440 (2003-10-01), Quinn et al.
patent: WO9713410 (1997-04-01), None
D H Hoch, et al. Channels Formed by Botulinum, Tetanus, and Diphtheria Toxins in Planar Lipid Bilayers: Relevance to Translocation of Proteins across Membranes. Proc. Natl. Acad. Sci. USA (1985) 82, 1692-1696.*
Benoliel, Rafael, et al., “Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain,”Pain(1999) 79: 243-253.
Bergstrom, Lena et al., “Sulfhydryl reagents have different effects on substance P and Neurokinin B binding sites on cortical synaptosomes in the Rat,”Neuropeptides(1987) 9: 151-159.
Buechler, Ying Ji, et al., “Synthesis and characterization of a homogeneouse chemical conjugate between basic fibroblast growth factor and saporin,”Eur. J. Biochem.(1995) 234: 706-713.
Faulstich, Heinz, et al., “Interchain and intrachain crosslinking of actin thiols by a bifunctional thiol reagent,”FEBS Letters(1992) 302(3): 201-205.
Fisher, Caroline E., et al., “Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: In vitro destruction of cells bearing substance P receptors,” Proc. Natl. Acad. Sci. USA(1996) 93: 7341-7345.
FitzGerald, David J., “Construction of Immunotoxins UsingPseudomonasExotoxin A,”Methods in Enzymology(1987) 151: 139-145.
FitzGerald, D.J., “How can we target cytotoxins to destroy subclasses of nociceptors?, ”Towards a New Pharmacotherapy of Pain(1991) John Wiley & Sons Ltd., pp. 69-81.
Goettl, Virginia M., et al., “An antagonist of substance P N-terminal fragments, D-substance P(1-7), reveals that both nociceptive and antinociceptive effects are induced by substance P N-terminal activity during noxious chemical stimulation,”Brain Research(1998) 780: 80-85.
Iadarola, Michael J., et al., “Good Pain, Bad Pain,”Science(1997) 278: 239-240.
Mansfield, Elizabeth, et al., “Characterization of RFB4-Pseudomonasexotoxin A immunotoxins targeted to CD22 on B-cell malignancies,”Bioconjugate Chem.(1996) &: 557-563.
Mantyh, Patrick W., et al., “Inhibition of hyperalgesia by ablation of lamina 1 spinal neurons expressing the substance P receptor,”Science(1997) 278: 275-279.
Theuer, Charles P., “Immunotoxins made with a recombinant form ofPseudomonasexotoxin A that do not require proteolysis for activity,”Cancer Research(1993) 53: 340-347.
Wiley, R.G., et al., “Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats,”Neuroscience Letters(1997) 230: 97-100.
FitzGerald David J.
Iadarola Michael J.
Campell Bruce R.
Kosar Andrew D.
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
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