Disubstituted polycyclic systems as cognition enhancers

Details Disubstituted polycyclic systems as cognition enhancers Disubstituted polycyclic systems as cognition enhancers

1996-03-25

1997-12-16

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514292, 544333, 544405, 546 84, 546285, C07D40104, C07D40304, A61K 3144, A61K 31505

Patent

active

056985592

ABSTRACT:
Compounds of Formula I have been shown to enhance the release of the neurotransmitter acetylcholine, and thus may be useful in the treatment of diseases of man, such as in Alzheimer's disease and other conditions involving learning and cognition, where subnormal levels of this neurochemical are found.
The compounds of this invention can be described as shown in Formula I ##STR1## where Q is ##STR2## R.sup.1 is 4-, 3-, or 2-pyridyl, pyrimidyl, pyrazinyl, or fluoro-4-pyridyl;

REFERENCES:
patent: 4760083 (1988-07-01), Myers et al.
patent: 5173489 (1992-12-01), Earl et al.

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