Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-12-27
1979-12-04
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544366, 544367, A61K 3150, C07D41714
Patent
active
041772725
ABSTRACT:
Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl,
X is nitrogen and simultaneously Y is oxygen or sulfur, or
X is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, and
R is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl.
These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.
REFERENCES:
patent: 3489757 (1970-01-01), Koppe et al.
patent: 3808210 (1974-04-01), Regnier et al.
patent: 3917597 (1975-11-01), Regnier et al.
patent: 3944551 (1976-03-01), Regnier et al.
Canevari Roger
Laubie Michel
Poignant Jean-Claude
Regnier Gilbert
Behr Omri M.
Coughlan, Jr. Paul M.
Science Union et Cie
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