Disubstituted phthalazine hedgehog pathway antagonists

Details Disubstituted phthalazine hedgehog pathway antagonists Disubstituted phthalazine hedgehog pathway antagonists

2011-07-19

2011-07-19

Ward, Paul V. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S237000

Reexamination Certificate

active

07981892

ABSTRACT:
The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer.

REFERENCES:
patent: 3753988 (1973-08-01), Rodway et al.
patent: 5985878 (1999-11-01), Stokbroekx et al.
patent: 6432970 (2002-08-01), Beachy et al.
patent: 2009/0048259 (2009-02-01), Austin et al.
patent: 2010/0324048 (2010-12-01), Hipskind et al.
patent: WO 97/26258 (1997-07-01), None
patent: WO 99/52534 (1999-10-01), None
patent: WO 00/74706 (2000-12-01), None
patent: WO 03/088970 (2003-10-01), None
patent: WO 2004/020599 (2004-03-01), None
patent: 2005/033288 (2005-04-01), None
patent: WO 2005/080378 (2005-09-01), None
patent: WO 2006/004589 (2006-01-01), None
patent: 2006/028958 (2006-03-01), None
patent: WO 2008/028689 (2008-03-01), None
patent: 2008/110611 (2008-09-01), None
patent: 2009/002469 (2008-12-01), None
patent: WO 2009/035568 (2009-03-01), None
patent: WO 2009/134574 (2009-11-01), None
patent: WO 2010/007120 (2010-01-01), None
patent: WO 2010/056588 (2010-05-01), None
patent: WO 2010/056620 (2010-05-01), None
patent: WO 2010/062507 (2010-06-01), None
Pinedo et al, “Translational Research . . . ”, The Oncologist 2000; 5(suppl1); 1-2. [www.The Oncologist.com].
McMahon, G., VEGF Receptor Signaling in Tumor Angiogenisis. The Oncologist 2000;5(suppl 1):3-10. [www.The Oncologist.com].
Frank-Kamenetsky, M., et al., “Small-molecular modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists,” Journal of Biolology vol. 1, Issue 2, Article 10, pp. 10.1-10.19 (2002).
Lee, J., et al., “A small-muleclar antagonist of the Hedgehog signaling pathway,” ChemBioChem, vol. 8, pp. 1916-1919 (2007).
Tremblay, M., et al., “Semisynthetic cyclopamine analogues as potent and orally bioavailable Hedgehog pathway antagonists,” J. Med. Chem., vol. 51, pp. 6646-6649 (2008).
Tremblay, M., et al., “Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy,” Expert Opin. Ther. Patents 19(8):1039-1056 (2009).

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