Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-iso

Details Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-iso Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-iso

1995-05-09

1997-06-10

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 536 41, 536 176, 536 179, A61K 3170, C07H 1500

Patent

active

056375700

ABSTRACT:
Novel dlsubstituted and trisubstituted derivatives of 2,3:4,6-di-O-isopropylidene-.alpha.-L-xylo-2-hexulofuranosonic acid containing at least one alkyl group at position 1, position 4 being occupied by OH, O-alkylamino or O-alkylaminoheterocyclic moiety, and the OH group at position 6 being replaced by a saturated heterocyclic moiety or aminoalkyl heterocyclic group. These compounds exhibit anti-cancer, anti-inflammatory and/or anti-proliferative activities. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating cancer, inflammatory and/or autoimmune disorders employing the compounds are described.

REFERENCES:
patent: 5010058 (1991-04-01), Ronsen et al.

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