Disubstituted and deoxydisubstituted derivatives of .alpha.-d-ly

Details Disubstituted and deoxydisubstituted derivatives of .alpha.-d-ly Disubstituted and deoxydisubstituted derivatives of .alpha.-d-ly

1992-08-21

1994-11-22

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 172, 536 175, 536 41, 536 111, 536 187, 536 286, 536 186, 536 185, 536 54, 536 55, 536 291, 536 221, 536 173, 536 281, 536 2911, 514 23, 514 32, 514 24, C07H 1504, C07H 1702

Patent

active

053670620

ABSTRACT:
Derivatives of disubstituted and deoxydisubstituted .alpha.-D-lyxofuranosides and intermediates for preparing these derivatives are described. These compounds exhibit significant antiinflammatory and anti-proliferative activity and are useful for treating inflammatory and/or autoimmune disorders such as psoriasis, asthma, atopic dermatitis, rheumatoid arthritis, osteoarthritis, scleroderma, systemic lupus erythematosus, and cancer (particularly melanoma and colon cancer).

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Barbat et al, "Reactions of D-lyxose and D-xylose with 2 methoxypropene," Carb. Res. 219: 115-121 (1991).
Schmidt, "Isopropylidene Derivates," in "Methods in Carbohydrate Chemistry," Whistler et al. (Eds.), (1963), pp. 318-325.
Pigman, "Chemistry of Carbohydrates," pp. 189-193, 228-231 (1948).
Morrison & Boyd, "Organic Chemistry" (4th Ed.), pp. 523-524 (1983).
The Merck Index, Windholz et al (Eds.), (1983), pp. 1231.

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