Disubstituted acetylenes bearing heteroaromatic and heterobicycl

Details Disubstituted acetylenes bearing heteroaromatic and heterobicycl Disubstituted acetylenes bearing heteroaromatic and heterobicycl

1989-03-20

1992-02-18

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514247, 514269, 514255, 514432, 514444, 514456, 514461, 514863, 544238, 544333, 544376, 549 13, 549 23, 549 60, 549398, 549425, 549426, 549427, 546269, 546274, A61K 31335, A61K 3138, C07D41306, C07D41312

Patent

active

050895095

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-2; and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4307108 (1981-12-01), Belletire et al.
patent: 4739098 (1988-04-01), Chandraratna
patent: 4810804 (1989-03-01), Chandraratna
patent: 4895868 (1990-01-01), Chandraratna
J. Med. Chem., 1987, vol. 30, No. 8, pp. 1474-1482, Spruce et al.
J. Med. Chem., 1984, vol. 27, pp. 1516-1531, Dawson et al.

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