Disubstituted acetylenes bearing heteroaromatic and heterobicycl

Details Disubstituted acetylenes bearing heteroaromatic and heterobicycl Disubstituted acetylenes bearing heteroaromatic and heterobicycl

1991-11-15

1993-08-10

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514269, 514314, 544238, 544242, 544335, 544336, 544406, 546166, A61K 41435, C07D40104, C07D23926

Patent

active

052349268

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-2; and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

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