Disubstituted acetylenes bearing heteroaromatic and heterobicycl

Details Disubstituted acetylenes bearing heteroaromatic and heterobicycl Disubstituted acetylenes bearing heteroaromatic and heterobicycl

1994-10-14

1997-02-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514253, 514255, 514256, 514269, 514314, 514337, 514432, 514444, 514456, 514461, 514863, A61K 31505, A61K 31495, A61K 3138, A61K 3147

Patent

active

056021305

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-4; and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

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