Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1997-07-09
1999-08-17
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
4352992, 4353041, 4353043, C12M 306
Patent
active
059393149
ABSTRACT:
A method for making a biocompatible polymer article using a uniform atomic oxygen treatment is disclosed. The substrate may be subsequently optionally grated with a compatibilizing compound. Compatibilizing compounds may include proteins, phosphorylcholine groups, platelet adhesion preventing polymers, albumin adhesion promoters, and the like. The compatibilized substrate may also have a living cell layer adhered thereto. The atomic oxygen is preferably produced by a flowing afterglow microwave discharge, wherein the substrate resides in a sidearm out of the plasma. Also, methods for culturing cells for various purposes using the various membranes are disclosed as well. Also disclosed are porous organic polymers having a distributed pore chemistry (DPC) comprising hydrophilic and hydrophobic regions, and a method for making the DPC by exposing the polymer to atomic oxygen wherein the rate of hydrophilization is greater than the rate of mass loss.
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Barr Hardie R.
Beisner William H.
The United States of America as represented the Administrator of
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