Chemistry: molecular biology and microbiology – Apparatus
Patent
1997-07-09
1999-08-10
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
435180, 4352971, 4352975, 4352991, 4352992, 427596, 521 27, 21050027, 21050036, C12M 112, C12N 1108
Patent
active
059358459
ABSTRACT:
A method for making a biocompatible polymer article using a uniform atomic oxygen treatment is disclosed. The substrate may be subsequently optionally grated with a compatibilizing compound. Compatibilizing compounds may include proteins, phosphorylcholine groups, platelet adhesion preventing polymers, albumin adhesion promoters, and the like. The compatibilized substrate may also have a living cell layer adhered thereto. The atomic oxygen is preferably produced by a flowing afterglow microwave discharge, wherein the substrate resides in a sidearm out of the plasma. Also, methods for culturing cells for various purposes using the various membranes are disclosed as well. Also disclosed are porous organic polymers having a distributed pore chemistry (DPC) comprising hydrophilic and hydrophobic regions, and a method for making the DPC by exposing the polymer to atomic oxygen wherein the rate of hydrophilization is greater than the rate of mass loss.
REFERENCES:
patent: 4619897 (1986-10-01), Hato et al.
patent: 5141806 (1992-08-01), Koontz
patent: 5332551 (1994-07-01), Koontz
Barr Hardie R.
Beisner William H.
The United States of America as represented by theAdministrator,
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