Chemistry: molecular biology and microbiology – Apparatus
Patent
1994-06-03
1998-08-25
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
435180, 435240243, 4352971, 4352975, 4352991, 4352992, 427569, 521 27, 21050027, 21050036, C12M 112, C12N 1108
Patent
active
057982619
ABSTRACT:
A method for making a biocompatible polymer article using a uniform atomic oxygen treatment is disclosed. The substrate may be subsequently optionally grated with a compatibilizing compound. Compatibilizing compounds may include proteins, phosphorylcholine groups, platelet adhesion preventing polymers, albumin adhesion promoters, and the like. The compatibilized substrate may also have a living cell layer adhered thereto. The atomic oxygen is preferably produced by a flowing afterglow microwave discharge, wherein the substrate resides in a sidearm out of the plasma. Also, methods for culturing cells for various purposes using the various membranes are disclosed as well. Also disclosed are porous organic polymers having a distributed pore chemistry (DPC) comprising hydrophilic and hydrophobic regions, and a method for making the DPC by exposing the polymer to atomic oxygen wherein the rate of hydrophilization is greater than the rate of mass loss.
REFERENCES:
patent: 3702973 (1972-11-01), Daugherty et al.
patent: 3826226 (1974-07-01), Clark
patent: 3864250 (1975-02-01), Perry
patent: 3904366 (1975-09-01), Grasenick
patent: 4143949 (1979-03-01), Chen
patent: 4268711 (1981-05-01), Gurev
patent: 4346142 (1982-08-01), Lazear
patent: 4362632 (1982-12-01), Jocob
patent: 4394457 (1983-07-01), Ogasa
patent: 4544485 (1985-10-01), Pinkerton et al.
patent: 4560599 (1985-12-01), Regen
patent: 4583492 (1986-04-01), Cowher et al.
patent: 4608063 (1986-08-01), Kurokawa
patent: 4619897 (1986-10-01), Hato et al.
patent: 4686113 (1987-08-01), Delfino et al.
patent: 4756794 (1988-07-01), Yoder
patent: 4786603 (1988-11-01), Wielinger et al.
patent: 4794002 (1988-12-01), Henis et al.
patent: 4851121 (1989-07-01), Yokota et al.
patent: 4885077 (1989-12-01), Karakelle et al.
patent: 4885086 (1989-12-01), Miura
patent: 4919659 (1990-04-01), Horbett et al.
patent: 5026650 (1991-06-01), Schwarz et al.
patent: 5028453 (1991-07-01), Jeffrey et al.
patent: 5098569 (1992-03-01), Stedronsky
patent: 5104729 (1992-04-01), Stedronsky
patent: 5139881 (1992-08-01), Henis et al.
patent: 5141806 (1992-08-01), Koontz
patent: 5209849 (1993-05-01), Hu et al.
patent: 5215790 (1993-06-01), Koontz
patent: 5282965 (1994-02-01), Urairi et al.
patent: 5332551 (1994-07-01), Koontz et al.
patent: 5356936 (1994-10-01), Howell et al.
patent: 5369012 (1994-11-01), Koontz et al.
patent: 5384042 (1995-01-01), Afeyan et al.
patent: 5510195 (1996-04-01), Sano et al.
WPIDS Abstract No. 87-293088 Abstract of Patent DE 3712491 (Sep. 22, 1993).
Tsai, Chi-Chun et al., "Enhanced Albumin Affinity of Silicone Rubber," Transactions of the American Society of Artificial Organs Internal Organs (ASAIO), vol. XXXIV, pp. 559-563(1988).
Tsai, Chi-Chun et al., "Biocompatible Coatings with High Albumin Affinity," Transactions of the American Society of Artificial Organs Internal Organs (ASAIO), vol. XXXVI, pp. M307-M310 (1990).
C. Stimpson et al., "Patency and Durability of Small Diameter Silicone Rubber Vascular Prosthesis," Biomaterials, Artificial Cells, and Artificial Organs, 17(1), (1989), pp. 31-43.
Durrani et al., "Modification of Polymer Surfaces for Biomedical Applications," Polymer Surfaces and Interfaces, Chapter 10, J. Wiley and Sons, (1987), pp. 189-200.
Rajender Sipehia, "FTIR-ATR Spectra of Protein A Immobilized on to Functionalized Polypropylene Membranes of Gaseous Plasma of Oxygen and of Anhydrous Ammonia," Biomaterials, Artificial Cells, and Artificial Organs, 16(5), (1988-1989), pp. 955-966.
Rajender Sipehia, "The Enhanced Attachment and Growth of Endothelial Cells on Anhydrous Ammonia Gaseous Plasma Modified Surfaces of Polystyrene and Poly(Tetrafluoroethylene)," Biomaterials, Artificial Cells, and Artificial Organs, 18(3), (1990), pp. 437-446.
Elizabeth G. Nabel et al., "Recombinant Gene Expression in Vivo Within Endothelial Cells of the Arterial Wall," Science, vol. 244, 16 Jun. 1989, pp. 1342-1345.
Hiroo Iwata et al., "Preparation and Properties of Novel Environment-Sensitive Membranes Prepared by Graft Polymerization onto a Porous Membrane," Journal of Membrane Science, vol. 38, (1988), pp. 185-199.
J. Wolff, "Tailoring of Ultrafiltration Membranes by Plasma Treatment and Their Application for the Desalination and Concentration of Water-Soluble Organic Substances," Journal of Membrane Science, vol. 36, (1988), pp. 207-214.
F. Vigo et al., "Poly (Vinyl Chloride) Ultrafiltration Membranes Modified by High Frequency Discharge Treatment," Journal of Membrane Science, vol. 36, (1988), pp. 187-199.
F. F. Stengaard, "Preparation of Asymmetric Microfiltration Membranes and Modification of Their Properties by Chemical Treatment," Journal of Membrane Science, vol. 36, (1988), pp. 257-275.
Fang Yuee et al., "Polypropylene Dialysis Membrane Prepared by Cobalt-60 Gamma-Radiation-Induced Graft Copolymerization," Journal of Membrane Science, vol. 39, (1988), pp. 1-9.
H. K. Yasuda et al., "Plasma-Surface Interactions in the Plasma Modification of Polymer Surfaces," Polymer Sciences and Interfaces, Chapter 8, J. Wiley and Sons, 1987, pp. 149-162.
Attar S. Chawla, "Use of Plasma Polymerization for preparing Silicone-Coated Membranes for Possible Use in Blood Oxygenators," Artificial Organs, vol. 3(1), (1979), pp. 92-96.
Y. Ikada, "Development of a Polymer Surface with Non-Adherent Platelet Properties," Polymers in Medicine and Surgery, Plastics and Rubber Institute and Science and Technology Publishers, Homchurch, UK, (1986), pp. 6/1-16/8.
Barr Hardie R.
Beisner William H.
The United States of America as represented by the Administrator
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