Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Reexamination Certificate
2006-11-22
2010-02-23
Arana, Louis M (Department: 2831)
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
C600S420000
Reexamination Certificate
active
07667460
ABSTRACT:
Magnetic resonance monitoring of a target (30) uses the detected magnetic resonance to determine movement such as diffusion of contrast agent relative to the object, and uses the movement to discriminate (50, 60) a part of the contrast agent which is bound to the target, from the rest of the contrast agent. The need for clearing agents can be avoided or reduced, and hence imaging is instantaneous. A “stationary spin map” of the object can be formed by comparing the movements in the different directions, and determining if the differences between them are less than a given threshold. Determining isotropic movement in this way for a number of locations on the object allows the map to be generated.
REFERENCES:
patent: 5345175 (1994-09-01), Kasuboski et al.
patent: 6198960 (2001-03-01), Fain et al.
patent: 6205349 (2001-03-01), Kim et al.
patent: 6861045 (2005-03-01), Lauffer et al.
patent: 2004055539 (2004-07-01), None
patent: 2005079274 (2005-09-01), None
Boesch, C., et al.; Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle; 2001; NMR in Biomedicine; 14:140-148.
Clark, C. A., et al.; Water Diffusion Compartmentation and Anisotropy at High b Values in the Human Brain; 2000; MRM; 44:852-859.
Dreher, W., et al.; Changes in Apparent Diffusion Coefficients of Metabolites in Rat Brain After Middle Cerebral Artery Occlusion Measured by Proton Magnetic Resonance Spectroscopy; 2001; MRM; 45:383-389.
Govindan, S. V., et al.; Use of Galactosylated-Streptavidin as a Clearing Agent with 111In-Labeled, Biotinylated Antibodies to Enhance Tumor/Non-Tumor Localization Ratios; 2002; Cancer Biotherapy & Radiopharmaceuticals; 17 (3)307-316.
Morawski, A. M., et al.; Quantitative “Magnetic Resonance Immunohistochemistry” with Ligand-Targeted 19F Nanoparticles; 2004; MRM; 52:1255-1262.
Aime, S., et al.; Highly Sensitive MRI Chemical Exchange Saturation Transfer Agents Using Liposomes; 2005; Angew. Chem. Int. Ed.; 44:5513-5515.
Nolte, U. G., et al.; Rapid Isotropic Diffusion Mapping Without Susceptibility Artifacts: Whole Brain Studies Using Diffusion-Weighted Single-Shot Steam MR Imaging; 2000; MRM; 44:731-736.
Sarlls, J. E., et al.; Isotropic Diffusion Weighting in Radial Fast Spin-Echo Magnetic Resonance Imaging; 2005; MRM; 53:1347-1354.
Gruell Holger
Lamerichs Rudolf Mathias Johannes Nicolaas
Pikkemaat Jeroen Alphons
Wegh Rene Theodorus
Arana Louis M
Koninklijke Philips Electronics , N.V.
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