Distamycin derivatives and process for their preparation

Details Distamycin derivatives and process for their preparation Distamycin derivatives and process for their preparation

1985-10-03

1988-04-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548518, A61K 3140, C07D40314

Patent

active

047389800

ABSTRACT:
Distamycin A derivatives of formula ##STR1## wherein R is (a)--NHR.sub.3, wherein R.sub.3 is

REFERENCES:
patent: 3420844 (1969-01-01), Arcamore et al.
patent: 3420845 (1969-01-01), Arcamore et al.
patent: 3432522 (1969-03-01), Preau
Nikitin, S. M., "DNA Base Pair Sequence-Specific Ligands . . . ", Chemical Abstracts, vol. 95, 1981, p. 32; 95:35304r.
Grehn, L. "Synthesis and Antiviral Activity of Distamycin A Analogues . . . ", J. Med. Chem., 1983, 26, 1042-1049.
Taylor, J. S. et al, "DNA Affinity Cleaving" Tetrahedron 40,3,457 (1984).
Schultz, P. G. et al, "Sequence Specific Double Strand Cleavage of DNA by Bis(EDTA-DistamycinFC.sup.II) and EDTA-Bis(Distamycin)Fe.sup.II " Am. Chem. Soc. 105,26,7748 (1983).
Arcamone, F. "On Distamycin and Related Compounds, Selective Antiviral Agents" Med. Chem. 1972, pp. 29-45.
Bialer, M. et al, "Structure-Activity Relationship . . . " Jour. of Med. Chem., 1979, vol. 22, No. 11, pp. 1296-1301.
Chandra, P. et al, "Some Structural Requirements for the Antibiotic Action of Distamycin" FEBS Letters, vol. 16, No. 4, Sep. 1971 pp. 249-252.
Kuroyedov, A. A. et al, "Distamycin A and its Analogs as Agents for Blocking of Endo R. EcoRI Activity" Gene, 1(1977) 389-395.
Arcamone, F. et al, "Structure and Synthesis of Distamycin A" Nature, Sep. 5, 1964, vol. 203, pp. 1064-1065.
Luck, G. et al, "Specific Interactions of Distamycin A . . . " Nucleic Acids Research, vol. 4, No. 8, Aug. 1977, pp. 2655-2671.
Kopka, M. L. et al, "The Molecular Origin of DNA-Drug Specificity . . . " Proc. Natl. Acad. Sci. USA vol. 82, pp. 1376-1380, Mar. 1985, Biochemistry.
Youngquist, R. S. et al, "Sequence-Specific Recognition . . . Proc. Natl. Acad. Sci. USA vol. 82, pp. 2565-2569 May 1985, Biochemistry.
Chemical Abstracts: 68:21767z, 68:21768a, 88:83397a, 88:201h, 97:215877e, 82:25984e, 99:176269c, 95:61898g, 89:102109x, 81:163162r, 100:39669h.
Chem. Abstracts: 84:150434t, 90:87174q, 88:50585g.
Chemical Abstracts: 68:87088k, 71:101629h, 71:101631c.
Chem. Abstracts: 79:38445t.
Chem. Abstracts: 77:14824y, 76:108639y, 76:149456e.
Penco, S. et al, "Distamicina A-Nota II . . . " Gazz. Chim. Ital., 97(1967) pp. 1110-1115.
Martinez, J. "Activated N-Nitrosocarbomates for . . . " J. Med. Chem. 1982, 25 pp. 178-182.
Chandra, et al. "Some Structrual Requirements for the Antibiotic . . . " Feb. Letters, Jan. 1972, vol. 19 #4, pp. 327-330.
Waehnert, U. et al, "Dependent Inactivation of the DNA . . . " Chemical Abstracts, vol. 83, 1975 p. 252.
Zimmer, C. et al, "Binding of Analogs of the Antibiotics . . . " Chemical Abstracts, vol. 76, 1972, p. 180.
Nikitin, S. M. et al, "DNA Base Pair Sequence Specific Ligands . . . " Institute of Molecular Biology, Academy of Science of the USSR, Moscow, pp. 542-551.

Affiliated with

Also associated with

Rating

Distamycin derivatives and process for their preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Distamycin derivatives and process for their preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Distamycin derivatives and process for their preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2175568