Dissolution testing apparatus calibrator and method

Details Dissolution testing apparatus calibrator and method Dissolution testing apparatus calibrator and method

2007-04-18

2009-11-10

Raevis, Robert R (Department: 2856)

Measuring and testing

Testing of material

C073S861080

Reexamination Certificate

active

07614316

ABSTRACT:
A method is provided for probing the effective hydrodynamic flow of a liquid at various positions within a dissolution testing apparatus. The method includes embodiments of an appropriate electrode probe, and methods of generating a signature pattern from the sampled current that may be used to characterise the hydrodynamic flow of the liquid in the apparatus. The signature pattern may be used to validate and qualify the performance of the dissolution apparatus, diagnose problems with dissolution apparatus, predict the initial dissolution rate of a drug, or determine the local flow rate around specific parts of a drug.

REFERENCES:
Foster, T., Brown, W.; USP Dissolution Calibrators: Re-examination and Appraisal; Dissolution Technologies (Feb. 2005), pp. 6-8.
Gray, V., Barat, M., Bhattacharyya, P., Burrnicz, J., Crist, B., et al.; Activities of the USP Project Team on Dissolution Calibration. Dissolution Technologies (Feb. 2005), pp. 35-36.
Kukura, J., Baxter, J.L., Muzzio, F.J; Shear Distribution and Variability in the USP ‘Apparatus 2’ Under Turbulent Conditions; International Journal of Pharmaceuticals. 279; 2004; pp. 9-17.
Mirza, T.; Mechanical Versus Chemical Dissolution Calibration; Dissolution Technologies 2; Article 1; 2000.
Glowacki, P.; On the Use of Electrochemical Sensors for Local Velocity Measurement of Viscoelastic Fluids. Wärme- und Stoffübertragung 24, 177-181 (1989).
Deslouis, C., Tribollet, B., Tihon, J.; Near-Wall Turbulence in Drag Reducing Flows Investigated by the Photolithography-Electrochemical Probes. J. Non-Newtonian Fluid Mech. 123 (2004) 141-150.
Deslouis, C., Huet, F., Gil, O., Tribollet, B.; Spectral Analysis of Wall Turbulence with a Bicircular Electrochemical Probe. Experiments in Fluids 16, 97-104 (1993).
Amadi, S.A., Gabe, D.R., Goodenough, M.; An Electrochemical Mass Transport Sensor to Study Agitation in Electroplating Processes. Journal of Applied Electrochemistry 21 (1991) 1114-1119.
Wu, J., Ye, J.; Micro Flow Sensor Based on Two Closely Spaced Amperometric Sensors. Lab Chip, 2005, 5, 1344-1347.
Unwin, P.R., Macpherson, J.V.; New Strategies for Probing Crystal Dissolution Kinetics at the Microscopic Level. Chemical Society Reviews, 1995, 109-119.
Rode, S., Midoux, N., Latifi, M.A., Storck, A., Saatdjian, E.; Hydrodynamics of Liquid Flow in Packed Beds: An Experimental Study Using Electrochemical Shear Rate Sensors. Chemical Engineering Science, vol. 49, No. 6, pp. 889-900, 1994.
Rode, S., Latifi, M.A., Storck, A., Midoux, N.; An Experimental Study of the Frequency Response of Electrochemical Sensors in Nonhomogeneous Flow in Packed Beds. Journal of Applied Electrochemistry 24 (1994) 639-646.

Affiliated with

Also associated with

Rating

Dissolution testing apparatus calibrator and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dissolution testing apparatus calibrator and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dissolution testing apparatus calibrator and method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4067635