Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1988-01-04
1990-05-22
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
514772, 514832, A61K 4904, A61K 4700
Patent
active
049276239
ABSTRACT:
Biocompatible fluorocarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen. A method of preparing biocompatible fluorocarbon emulsions includes preparing a mixture of an emulsifying agent, osmotic agent, buffering agent, aqueous phase and fluorocarbon, forcing the mixture under high pressure into a cavity, against a surface and around a lip to cause turbulence and possibly cavitation to form high fluorocarbon concentration emulsions that are stable through heat sterilization; and, even when oxygenated, maintain substantially stable partial pressures of oxygen and of carbon dioxide, and substantially stable pH. A method of oxygenating high fluorocarbon concentration emuslions includes placing a measured amount of the emulsion in a container and causing the emulsion to form a thin film around the inner surface of the container when the oxygen is injected. An alternative method of oxygenating the high fluorocarbon concentration emulsion includes a two container system where one container, permeable to the to be dissolved gas, is formed within the other, and the emulsion is injected in one container and the to be dissolved gas is injected into the other container.
REFERENCES:
patent: 3818229 (1974-06-01), Long, Jr.
patent: 3975512 (1976-08-01), Long
patent: 4073879 (1978-03-01), Long, Jr.
patent: 4105798 (1978-08-01), Moore et al.
patent: 4116336 (1978-09-01), Sorensen et al.
patent: 4146499 (1979-02-01), Rosano
patent: 4151108 (1979-04-01), Sorensen et al.
patent: 4163734 (1979-08-01), Sorensen et al.
patent: 4299728 (1981-11-01), Cormier et al.
patent: 4369127 (1983-01-01), Cormier et al.
patent: 4397870 (1983-08-01), Sloviter
patent: 4423077 (1983-12-01), Sloviter
patent: 4451251 (1984-05-01), Osnterholm
patent: 4769241 (1988-09-01), Heldebrant et al.
Riess, J. G., Artificial Organs, 8:49, (1984).
Mottram, J. C., British Journal of Radiology, 8:32, (19835).
Davis, S. S., Advances in Clinical Nutrition MTP Press, Ltd., Boston: 1982, pp. 228-229.
Goodin et al., 245 American Journal of Physiology, pp. H519-H523, (1983).
Geyer, R., Perfluorocarbon Blood Substitutes, Intl. Symp. on Artificial Blood Substitutes, Bari, Italy: Jun. 19-20, (1987), pp. 45-47.
Persico, D., et al., Journal of Org. Chem., 50:5156-5159, (1985).
Sharts, C. and H. Reese, J. Fluorine Chemistry, 11:637-641, (1978).
Yokoyama, K. et al., Fed. Proc., 34(6), 1478-1483, (1975).
Steiner, M. and J. Anastasi, J. Clin. Inv., 57:732-737, (1976).
Pandolfe, W. D. and R. R. Kinney, The National Meeting of the Amer. Inst. of Chem. Engin., Denver, Colo., Aug. 29, 1983.
Gould, S. et al., Assessment of a 35% Flurorcarbon Emulsion, J. of Trauma, 23(8):720-724, (1983).
Moss, G. Biomaterials, Artificial Cells, Artificial Organs, 15(2):333-336, (1987).
Geyer, R., Perfluorocarbons as Oxygen Transport Vehicles, 15(2):329-332, (1987).
Burgan, A., D. M. Long et al., 3rd Intl. Symp. on Blood Substitutes, Montreal: Jun. 18-22, (1987).
Police, A. M. et al., Critical Care Medicine, 12(2):96-98, (1985).
Bose, B. et al., Brain Research, 328:223-231, (1985).
Spears, J. et al., Circulation, (Abstracts), 68, (Supp. III), No. 317, Oct. 1983.
Ogbilby, J. et al., (with C. Long), American Heart Association, Nov. 16-19, 1987.
Nunn, G. R. et al., American J. of Cardiology, 52:203-205, (1983).
Patel, M. et al., Federation Proceedings, 29(5):1740-1745, (1970).
Itoh, Y. et al., Gan To Kagaku Ryoho, 11(4):864-72, (1984).
Rockwell, S., 3rd Intl. Symp. on Blood Substitutes, Montreal: Jun. 18-22, 1987.
Peck, W. W. et al., Invest. Radiology, 19:129, (1984).
Dobben, G. et al., Neuroadiology, 6:17-19, (1973).
Brahme, F. et al., Perfluorocarbon Bromides as Contast Media in Radiography of the Central Nervous System, Acta Radiologica, Supplemen, 347:459-466, (1975).
Liu, M. S. et al., "Myelography with Ferfluoroctylbromide: Comparison with Pantopaque", Investigative Radiology, 11(4):319-330, (1976).
Mattrey, R. F., Perfluorochemicals as U.S. Contrast Agents for Tumor Imaging and Hepatosplenography, Radiology, 163:339-343, (1987).
Mattrey, R. F., et al., 35th Annual Meeting of the Association of University Radiologists, Charleston, S.C., Mar. 22-27, (1987).
Long, D. M. et al., "Efficacy and Toxicity Studies with Radiopaque Perfluorocarbon," Radiology, 105(2):323-332, (1972).
Long, D. M. et al., Biomaterials, Artificial Cells, Artificial Organs, 15(2):417, Montreal: Jun. 18-22, (1987).
Arlen C., Long, D. M. et al., Biomaterials, Artificial Cells, Artificial Organs, vol. 15(2), pp. 431, Montreal: Jun. 18-22, (1987).
Burgan, A. et al., "Acute and Subacute Toxicity of 100% PFOB Emulsion", 5th Annual Mtng., Soc. of Magnetic Resonance in Medicine, Montreal: Aug. 18-22, (1986).
Long, D. et al., Intl. Symp., "Total Exchange Perfusion of Rats with Highly Concentrated Fluorocarbon Emulsions", Centenary of the Discovery of Fluorine, Paris: Aug. 25-29, (1986).
Alliance Pharmaceutical Corp.
Waddell Frederick E.
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