Dissolution liquid for drug in iontophoresis

Details Dissolution liquid for drug in iontophoresis Dissolution liquid for drug in iontophoresis

1996-06-06

1999-11-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424484, A61K 31785, A61F 1300

Patent

active

059938480

ABSTRACT:
A drug held or supported by an interface comprising a porous matrix is dissolved with a drug dissolution liquid containing a humectant, and the drug is transdermally delivered by iontophoresis. The humectant includes e.g. glycerin and other polyhydric alcohols, sugar alcohols, proline and other amino acids and acidic mucopolysaccharides. The concentration of the humectant may be about 1 to 50% by weight, and the concentration of proline or other amino acid or its salt may be about 1 to 30% by weight. The drug includes (1) a physiologically active peptide or protein with a molecular weight of 100 to 30,000 or (2) a nonpeptide physiologically active compound with a molecular weight of 100 to 1,000.

REFERENCES:
patent: 4593053 (1986-06-01), Jevne et al.
patent: 5135480 (1992-08-01), Bannon et al.
patent: 5158537 (1992-10-01), Haak et al.
patent: 5527797 (1996-06-01), Eisenberg et al.
Pharmazie 49, 1994.

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