Education and demonstration – Anatomy – physiology – therapeutic treatment – or surgery... – Anatomical representation
Patent
1996-01-31
1998-09-15
Smith, Jeffrey A.
Education and demonstration
Anatomy, physiology, therapeutic treatment, or surgery...
Anatomical representation
G09B 2328
Patent
active
058071156
ABSTRACT:
An automated dissolution apparatus and method that simulates the physiological condition of gastrointestinal tract has been developed. The invention is capable of continuously adjusting the pH and enzyme content of dissolution medium with consideration of the transit time of a pharmaceutical dosage form. The apparatus includes a pH meter with recorder, a dissolution tester, a UV spectrophotometer, a dissolution data recorder with processor, a personal computer and a printer. The present invention can adjust the pH and enzyme content of a dissolution medium based on the literature information of human gastrointestinal conditions and transit times of various pharmaceutical dosage forms. Use of the present invention not only can change the pH and enzyme content of dissolution medium continueously, but also can differentiate the change of drug release and effects of pH and enzyme content on the drug release rate of pharmaceutical formulations.
REFERENCES:
patent: 4335438 (1982-06-01), Smolen
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