Dissociation of ligand-binder complex using ultrasound

Details Dissociation of ligand-binder complex using ultrasound Dissociation of ligand-binder complex using ultrasound

1984-02-23

1986-10-07

Kepplinger, Esther M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

134 1, 134184, 20415742, 20415762, 422 69, 422 71, 422128, 435173, 436531, 436536, 436824, G01N 33543, G01N 33545, B06B 100, C12N 1300

Patent

active

046159843

ABSTRACT:
A ligand is dissociated from a binder specific for the ligand by directing a beam of ultrasound at the complex of ligand and binder. The procedure may be employed in a solid phase assay to separate a labeled form of ligand, employed as a tracer, from a binder supported on a solid support.

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patent: 3003707 (1961-10-01), Lecher
patent: 3492212 (1970-01-01), Searcy
patent: 3550586 (1970-12-01), Balamuth
patent: 3825481 (1974-07-01), Supitilov
patent: 4059685 (1977-11-01), Johnson
patent: 4180383 (1979-12-01), Johnson
patent: 4261828 (1981-04-01), Brunner et al.
patent: 4389253 (1983-06-01), Nishimura et al.

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