Surgery – Liquid medicament atomizer or sprayer
Patent
1998-10-26
2000-01-18
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
12820022, 12820312, 12820423, A61M 1100
Patent
active
060149698
ABSTRACT:
A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.
REFERENCES:
patent: 3187748 (1965-06-01), Mitchell et al.
patent: 3565070 (1971-02-01), Hanson et al.
patent: 3658059 (1972-04-01), Steil
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3814297 (1974-06-01), Warren
patent: 3826413 (1974-07-01), Warren
patent: 3861386 (1975-01-01), Harris et al.
patent: 3991304 (1976-11-01), Hillsman
patent: 4090642 (1978-05-01), Baker
patent: 4119096 (1978-10-01), Drews et al.
patent: 4294407 (1981-10-01), Reichi et al
patent: 4334531 (1982-06-01), Reichi et al.
patent: 4361401 (1982-11-01), Smith et al.
patent: 4465234 (1984-08-01), Maehara et al.
patent: 4469255 (1984-09-01), Hill et al.
patent: 4484577 (1984-11-01), Sackner et al.
patent: 4533082 (1985-08-01), Maehara et al.
patent: 4592348 (1986-06-01), Waters, IV et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4627432 (1986-12-01), Newell et al.
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4790305 (1988-12-01), Zoltan et al.
patent: 4790479 (1988-12-01), Matsumoto et al.
patent: 4803978 (1989-02-01), Johnson, IV et al.
patent: 4852582 (1989-08-01), Pell
patent: 4877989 (1989-10-01), Drews et al.
patent: 4896832 (1990-01-01), Howett
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4955945 (1990-09-01), Weick
patent: 4984158 (1991-01-01), Hillman
patent: 5033463 (1991-07-01), Cocozza
patent: 5134993 (1992-08-01), van der Linden et al.
patent: 5152456 (1992-10-01), Ross et al.
patent: 5207217 (1993-05-01), Cocozza et al.
patent: 5497944 (1996-03-01), Weston et al.
patent: 5544646 (1996-08-01), Lloyd et al.
Baum, et al., "A Novel Breath Actuated Piezo Electronic Inhaler," 3M Healthcare Product Bulliten, 3M House, Morley Street Loughborough. Leic S LE11EP, England (1 page total).
Byron, ed., Respiratory Drug Delivery CRC Press, Inc., Boca Raton, FL, (1990).
Costar.RTM. Life Science Filtration Catalog, "Nucleopore.RTM. Polycarbonate Membranes,"(1992) p. 7.
Newman, et al., "Deposition of Pressurized Aerosols in the Human Respiratory Tract,"Thorax 36:52-55 (1981).
Newman, et al., "Deposition of Pressurized Aerosols in the Lung Using Radio-Labeled Particles," Thorax 35:234 (1980).
Newman, et al., "How Should a Pressuized .beta.-adrenergic Bronchodilator be Inhaled?," Eur. J. Respir. Dis. 62:3-21 (1981).
Newman, et al., "Deposition of Pressurized Suspension Aerosols Inhaled Through Extension Devices .sup.1-3," Am. Rev. Respir. Dis. 124:317-320 (1981).
Lloyd Lester John
Lloyd Peter M.
Rubsamen Reid M.
Schuster Jeffrey Arthur
Aradigm Corporation
Bozicevic Karl
Francis Carol L.
Lewis Aaron J.
LandOfFree
Disposable package for use in aerosolized delivery of antibiotic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Disposable package for use in aerosolized delivery of antibiotic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Disposable package for use in aerosolized delivery of antibiotic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-557777