Surgery – Liquid medicament atomizer or sprayer
Patent
1993-12-14
1996-03-12
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
12820016, A61M 1100
Patent
active
054977630
ABSTRACT:
A disposable package is provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. The formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package preferably includes one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package is configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated in a manner so as to provide for repeatable dosing of drug to the patient.
REFERENCES:
patent: 3187748 (1965-06-01), Mitchell et al.
patent: 3565070 (1971-02-01), Hanson et al.
patent: 3658059 (1972-04-01), Steil
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3814297 (1974-06-01), Warren
patent: 3826413 (1974-07-01), Warren
patent: 3991304 (1976-11-01), Hillsman
patent: 4361401 (1982-11-01), Smith, Jr. et al.
patent: 4465234 (1984-08-01), Maehara et al.
patent: 4484577 (1984-11-01), Sackner et al.
patent: 4533082 (1985-08-01), Maehara et al.
patent: 4592348 (1986-06-01), Waters, IV et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4627432 (1986-12-01), Newell et al.
patent: 4648393 (1987-03-01), Landis et al.
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4790305 (1988-12-01), Zoltan et al.
patent: 4790479 (1988-12-01), Matsumoto et al.
patent: 4803978 (1989-02-01), Johnson, IV et al.
patent: 4852582 (1989-08-01), Pell
patent: 4877989 (1989-10-01), Drews et al.
patent: 4896832 (1990-01-01), Howlett
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 5152456 (1992-10-01), Ross et al.
Baum, E. A. et al., "A novel breath actuated piezo electronic inhaler" 3M Healthcare Product Bulletin, 3M House, Morley Street Loughborough. Leic S LE11 1EP, England (1 page total).
Byron, P. R., ed., Respiratory Drug Delivery CRC Press, Inc., Boca Raton, FL, (1990).
Costar.TM. Life Science Filtration Catalog, "Nucleopore.TM. Polycarbonate Membranes" (1992) p. 7.
Newman et al., "Deposition of pressurised aerosols in the human respiratory tract" Thorax (1981) 36:52-55.
Newman et al., "Deposition of pressurised aerosols in the lung using radio-labelled particles" Thorax (1980) 35:234.
Newman et al., "How should a pressurized .beta.-adrenergic bronchodilator be inhaled?" Eur. J. Respir. Dis. (1981) 62:3-21.
Newman et al., "Deposition of pressurized suspension aerosols inhaled through extension devices.sup.1-3 " Am. Rev. Respir. Dis. (1981) 124:317-320.
Lloyd Lester J.
Lloyd Peter M.
Rubsamen Reid M.
Aradigm Corporation
Bozicevic Karl
Lewis Aaron J.
LandOfFree
Disposable package for intrapulmonary delivery of aerosolized fo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Disposable package for intrapulmonary delivery of aerosolized fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Disposable package for intrapulmonary delivery of aerosolized fo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2094356